Targeting mitochondria, anti-aging also needs to be targeted
With the development and evolution of the cosmetics market, the concept of "precision skincare" has been proposed. In the past period, there has been a high demand for ingredient parties, who have been emphasizing the addition of various efficient or rare ingredients in products, attempting to attract consumers' curiosity with a stacked "ingredient pyramid".
Precision skincareThe focus of pursuit is different, emphasizing on skin targets and functional pathwaysAccurate anchoring, active ingredientsAccurate screeningAnd the functional ingredients for the skinAccurate deliveryThree levels. Based on this, the concept of "targeted skincare" has emerged, which is consistent with the medical idea of "targeted treatment", referring to finding the key target areas of skincare for targeted skin conditioning and improvement.
Mitochondrial targeted anti-agingIt is the application guided by this theory.
Mitochondria and anti-aging
During the process of mitochondrial replication and replacement in the human body, it can be damaged or degraded by factors such as oxidation and free radicals, resulting in inferior mitochondria. This can affect the ability and efficiency of mitochondrial energy conversion. If other organs in the body cannot obtain sufficient energy through mitochondria in a timely manner, it will affect their normal function.
Therefore, the decline in mitochondrial function in various tissues that occurs with age is a human phenomenonEndogenous agingMaintaining mitochondrial homeostasis is also considered a potential longevity mechanism in the field of aging.
Although cells can spontaneously form defense mechanisms to weaken the effects of free radical byproducts during mitochondrial energy production, they are only effective to a certain extent. Mitochondria also require potent antioxidants to eliminate free radicals and prevent early cellular aging. So,To maintain mitochondrial homeostasis, we can approach it from the perspective of enhancing mitochondrial antioxidant capacity.
Idebenone
Unlike other types of antioxidants,Adibenone is a respiratory chain antioxidant that targets mitochondria. Edebenone can activate cellular mitochondrial respiratory activity, promote cellular ATP synthesis, and effectively inhibit mitochondrial lipid peroxidation. It is a new generation of highly effective antioxidants and anti-aging ingredients.
Structurally, idebenone is a low relative molecular weight coenzyme Q10 analogue with stronger antioxidant capacity compared to coenzyme Q10. Adibenone protects cell membranes and mitochondria from oxidative damage caused by cellular metabolism by inhibiting lipid peroxidation, thus defending against endogenous aging. At present, mitochondria are becoming the golden target for precision skincare, and idebenone will be the best choice for mitochondrial targeted skincare efficacy ingredients.
Best Carrier ® idebenone 2
In response to the above issues, Baisi Kairui Company has developed innovative transdermal delivery nanocarrier technologyBest Carrier ® idebenone 2 efficiently delivers active ingredients into deep skin tissues, achieving targeted delivery to cells and mitochondria, thereby improving the bioavailability of active ingredients and achieving precise skincare.
At the same time, nano carriers can effectively improve the light and heat stability of idebenquinone, with high compatibility, easy to be compounded with various matrices such as cream/essence/lotion/water agent/facial mask, and suitable for transparent systems.
▶ Left: Best Carrier ® Adebenone 2; Right: 5% compound essence
Efficacy test
After multiple efficacy tests, we have verifiedBest Carrier ® idebenone 2 is a new anti-aging ingredient product with superior anti-aging effects.
▶ Franz diffusion cell was used for in vitro skin transdermal experiments, and the experimental results showed that the skin storage capacity of Best Carrier ® idebenone 2 could be increased by 150%;
▶ In vivo skin permeability studies have shown that Best Carrier ® idebenone 2 can effectively deliver active ingredients to deep skin tissues.
▶ The results of the cellular uptake experiment demonstrate that Best Carrier ® idebenone 2 is more easily taken up by human skin fibroblast (HSF) cells than free idebenone, and then reaches the target organelle - mitochondria.
▶ Research has also shown that Best Carrier ® idebenone 2 has significant antioxidant protection against oxidative damage in HSF cells and can effectively reduce intracellular ROS levels in HSF cells.
The evaluation results of the anti-aging efficacy of volunteer skin show thatBest Carrier ® idebenone 2 can effectively improve the texture and wrinkle levels of human skin. The HET-CAM experiment and patch test results also indicate Best Carrier ® Adibenone 2 is safe and non irritating.
At present, Baisikairui has developed a series of transdermal co delivery nanocarriers for anti-aging and wrinkle removal, with a total of 13 products. If you want to learn more about the product details, please feel free to consult Baisikairui and Aoxue Chemical.
Wuhan Baisi Kairui Biotechnology Co., Ltd. always adheres to the principle of "technological innovation, customer first", providing integrated services for the research and development, production, and application of nano carriers of cosmetic functional ingredients for a wide range of cosmetic brands and enterprises.
In the future, the company will continue to strengthen the research and development of nano carrier technology for cosmetic efficacy raw materials, promote the scientific application of nano carrier technology in efficacy cosmetics, improve the technological level of China's efficacy cosmetics industry, achieve precise skincare, and bring healthy, safe, and efficient new efficacy cosmetics to consumers.
