The full name of 377 is phenethyl resorcinol, which belongs to the resorcinol derivatives. It can effectively reduce the synthesis of melanin by inhibiting the activity of tyrosinase. According to reports, the activity of 377 inhibiting tyrosinase is 100 times that of arbutin and 22 times that of quercetin! It can improve uneven skin tone and reduce melanin deposition caused by ultraviolet radiation on the skin; At the same time, it also has super strong antioxidant and wrinkle resistance.

 

 
1: Low solubility and poor water dispersibility
 
2: Poor stability, unstable light and heat, and prone to discoloration
 
3: Skin irritation exists at high doses
 
4: Poor transdermal absorption and low bioavailability
 

 
1. High stability: effectively improves the light/thermal stability of SymWhite377

2. High compatibility: Good water dispersibility, easy to mix with various substrates, especially suitable for transparent systems

3. Low irritation: The carrier sustained-release effect effectively reduces skin irritation

4. High bioavailability: Active ingredients with different whitening mechanisms synergistically enhance efficacy, and the carrier promotes transdermal absorption of active ingredients, entering the whitening target site and effectively improving bioavailability
 

 

 

Invention patent: A co delivery nanocomposite of phenylethylresorcinol and its preparation method and application
Published paper: Cationic Nanoliposomes Efficiently Delivering Phenyletyl Resorcinol Produce Enhanced Skin Lightening Effect [J] Nano Life, 2020.