1、 Introduction to raw materials
Retinol is a natural vitamin A, and its derivatives are called the retinoid family, including retinaldehyde, retinoic acid (RA), retinyl esters, beta carotene, etc. Many classic brands and products consider retinoids as the first choice for antioxidant, anti-aging, and acne treatment. HPR (0.1% wt.) indeed has stronger stability compared to retinol (0.1% wt.). However, after 24 hours at a high temperature of 50 ℃, 50% of HPR still loses its activity.
2、 Application pain points
1: Poor stability, sensitive to air, heat, light, and temperature, and susceptible to losing physiological effects when exposed to ultraviolet radiation
2: Difficult to be absorbed through the skin, HPR targets the dermis layer and requires transdermal absorption to enter the dermis layer to exert its efficacy.
3: The function is single, and the aging mechanism of human skin is complex. HPR needs to be synergistically enhanced with other active ingredients.
3： Product advantages
1. High stability: effectively improves the light/thermal stability of HPR
2. Synergistic effect enhancement: Active ingredients with different mechanisms of action synergistically enhance efficiency
3. High compatibility: easy to mix various matrices such as cream/essence/lotion/water agent/facial mask, suitable for transparent system
4. High bioavailability: slow-release controlled release, increasing the retention of HPR in the skin, significantly improving bioavailability
4、 Patents and Papers
Invention Patent: A Multi effect Hydroxyfenone Retinoate Nanocomposite and Its Preparation Method and Application
(Patent number: CN202110175444.9)
