1、 Introduction to raw materials
Ceramide is a type of amide compound formed by dehydration of long-chain fatty acids and the amino group of sphingosine. It mainly includes ceramide phosphatidylcholine and ceramide phosphoethanolamine. Phospholipids are the main components of cell membranes, and 40% to 50% of sebum in the stratum corneum is composed of ceramides. Ceramide is the main part of the intercellular matrix and plays an important role in maintaining the balance of water in the stratum corneum. Ceramides have a strong ability to bind water molecules and maintain skin moisture by forming a network structure in the stratum corneum. Therefore, ceramides have the ability to maintain skin moisture
2、 Application pain points
1: Poor stability: high crystalline substance, low solubility, easy to crystallize and precipitate, damaging the stability of the formula
2: Poor applicability: low solubility, poor water dispersibility, difficult to apply in cosmetic formulations
3: Low bioavailability: Strong polarity, difficult to penetrate and absorb through the skin, difficult to stay in the skincare target area
4: Single effect limited: repairing the skin barrier requires multiple ceramides to synergistically enhance efficiency
3： Product advantages
1. Multiple ceramide complexes: ceramide NP, NS/NG, and AP are essential substances for repairing damaged and sensitive skin
2. Plant sphingosine: Plant sphingosine (PHS/PS) is a precursor of ceramides and also one of the lipid components of the skin. It is an important component for water retention and barrier function
3. Cholesterol: Cholesterol has a smooth and moisturizing effect, is non irritating to the skin, and is also a very necessary anti-inflammatory agent that helps with penetration
4、 Patents and Papers
Authorized patent: ZL201510770117.2, a high skin retention ceramide nanocomposite and its preparation method and use.
Published paper: Preparation and efficacy evaluation of ceramide IIIB nanoliposomes [J]. Daily Chemical Industry, 2016, 46 (9): 514-518
