Approaching the technology of transdermal co delivery nanocarriers for whitening efficacy ingredients
There is a saying that goes, 'One white covers up a hundred ugliness.' This is certainly an exaggerated expression, but fair skin gives people a delicate and clean feeling visually, so 'skin whitening' has become one of the symbols of 'beauty' in the eyes of most people. The current young population, especially women, are very concerned about and admire this.
(Image sourced from the internet)
Apart from internal factors such as genetics causing darker skin tone, most people turn black due to external stimuli. So what is the mechanism of skin darkening? What ingredients are more effective in whitening? Let's learn about it together.
Whitening mechanism
Firstly, let's briefly understand the process of skin darkening, which can be roughly represented by the following diagram:
Under the stimulation of factors such as ultraviolet radiation, the skin secretes a substance called melanocyte stimulating hormone (MSH), which transmits signals to melanocytes to produce melanin. The melanin produced by melanocytes after receiving signals moves layer by layer during cellular metabolism and is ultimately transported to the surface cells of the skin, thereby affecting skin color.
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Based on the pathway of melanin production, we can identify several main whitening pathways:
Cut off the signal of melanin activated cells;
Reduce the production of melanin;
❸ Prevent melanin transport;
Accelerate the metabolism of melanin in the stratum corneum.
Therefore, when designing whitening formulas, we should focus on ingredients with the above whitening mechanisms and intervene in each stage from melanin production to transfer.
The most commonly added ingredients to whitening product formulas in the currently used cosmetic ingredient catalog include resorcinol, arbutin, niacinamide, VC and its derivatives, and so on.
In recent years, the skincare market has responded positively to people's demand for whitening. All major brands are obsessed with research and development, hoping to create a popular "whitening artifact", so every year we can see many essence, lotion, creams, facial mask and other skin care products with whitening claims on the market.
There are also considerable effects among them, butAt present, there are generally the following problems with commercially available whitening products:
Poor solubility/stability：Some whitening ingredients have poor solubility and thermal stability, and are prone to decomposition and discoloration when exposed to light and heat;
❷ Low whitening efficiencyUnder the obstruction of the skin barrier, whitening ingredients are difficult to penetrate into the target area - the basal layer of the skin, as well as the target cells - melanocytes, resulting in low whitening efficiency;
❸ Stimulating：Some whitening ingredients have strong skin irritation at high doses;
❹ Single whitening efficacy ingredient：Lack of synergistic effects of functional components with different mechanisms of action.
To address these issues, based on over 20 years of research in the field of nanocarrier transdermal drug delivery, our team innovatively proposes the application of transdermal co delivery nanocarrier technology for the transdermal delivery of whitening active ingredients, effectively solving the problem of the application of active ingredients in whitening cosmetics and providing consumers with high-performance, safe, and effective new whitening cosmetic products.
New application of transdermal co delivery nanocarrier technology
Scientific combination&precise skincare
Our makeup and skincare products are also used on the skin, and those skincare ingredients are like drugs that need to penetrate deep into the skin to achieve better results.
Can the logic of transdermal drug delivery also be applied to skincare products? Using the same logic, we canEncapsulating different cosmetic functional ingredients in nanocarrier materials to construct transdermal co delivery nanocarriers, the carriers carry these ingredients through the surface of the skin, penetrate deep tissues, and reach target sites and cells, exerting synergistic effects.
Wuhan Baisi Kairui Biotechnology Co., Ltd. (hereinafter referred to as Baisi Kairui) has accumulated years of research and development production experience, and has become a leader in the industry in the technology of transdermal co delivery of cosmetic functional ingredients as nanocarriers.
Baisi Kairui has developed and produced a series of cosmetic efficacy ingredients through this technology, mainly including whitening and spot removal, moisturizing and hydrating, acne and oil control, soothing and anti allergic, anti-aging and wrinkle reducing, skin sensation regulation, compound sunscreen, and hair loss prevention.
Baisi Kairui Whitening Effect Raw Material Products
Best Carrier 377 5G White
Taking the whitening series of effective ingredients as an example. Unlike many single ingredient whitening products on the market, Baisikairui usesInnovative transdermal co delivery nanocarrier technology, which inhibits tyrosinase activity, melanin migration, antioxidant, anti-inflammatory, and enhances skin immunity through co delivery nanocarrier transdermal co absorption of different active ingredients, promotes the enrichment of active ingredients in whitening and skincare target areas (active epidermis) and target cells (melanocytes), greatly improves the stability of active ingredients, and achieves multi effect and multi-target whitening and brightening.
In addition, under the controlled release of nanocarriers, the active ingredients are slowly released, exerting long-lasting effects at the target site, effectively avoiding skin irritation and toxic side effects caused by high-dose release, and providing users with a milder and safer experience.
Security testing
In order to further ensure that the products are safe and non irritating to the human body, the Baisi Kairui whitening series raw materials have undergone skin toxicology testing in accordance with the "Technical Guidelines for Spot Removing and Whitening Special Cosmetics (Draft for Comments)" issued by the China National Medical Products Administration. We have specially commissioned a third-party testing agency accredited by the China National Accreditation Service for Conformity Assessment (CNAS) to obtain the qualification certification of inspection and testing institutions in the cosmetics field (CMA) for the Best Carrier developed by our company ® The whitening series efficacy ingredients have undergone skin toxicology testing, and the test results are safe and non irritating.
Baisi Kairui actively grasps the development trend of cosmetic efficacy raw materials, strives to promote the scientific application of transdermal co delivery nanocarrier technology in efficacy cosmetics, and improves the technological level of China's efficacy cosmetics industry.
We are committed to bringing healthy, safe, and efficient new high-performance cosmetics to consumers, and contributing to the beauty industry!
