Hair loss anxiety, forging a new market
Hair loss has become a disease of the times, with data showing that about half of men worldwide are troubled by hair loss issues. According to statistics, the number of people suffering from hair loss in China has reached 250 million, with males accounting for nearly 70%. The proportion of hair loss before the age of 30 is as high as 84%, and the post-90s generation has become the main group of people suffering from hair loss,Hair loss tends towards youthfulness.(Source: White Paper on Chinese Scalp Health, a survey of hair loss population conducted by China Health Promotion and Education Association).
Data shows that 36.1% of people who purchase hair loss prevention products online are born in the 1990s, and 38.5% are born in the 1980s. When we are lamenting that the first batch of post-90s generation have already started to lose their hair, it is not difficult to find that the Chinese anti hair loss market contains huge market potential.
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What causes hair loss?
Hair loss can be classified into two types based on pathology: scar induced hair loss (such as hair loss caused by burns, skin diseases, tumors, etc.) and non scar induced hair loss (androgenetic hair loss, alopecia areata, resting phase hair loss, etc.). amongAndrogenic alopeciaAndrogenetic alopecia (AGA) is the most common form of hair loss in clinical practice, accounting for approximately 90% of all types of hair loss.
The mechanism of action of androgenic alopecia is very complex, closely related to factors such as androgen secretion, androgen receptors, related cytokines/proteins, signaling pathways/proteins, etc.
Among them, abnormal expression of androgens and their receptors is an important influencing factor. Overexpressed androgens (testosterone) are reduced to dihydrotestosterone (DHT) under the action of 5 α - reductase. DHT binds to androgen receptors, causing subsequent cascade reactions, leading to hair follicle atrophy, long cycle shortening of hair, and ultimately hair loss.
Cytokines/proteins related to hair growth, such as VEGF, bFGF, TGF - β 1, IGF, β - catenin, etc., are also closely related to the occurrence and development of hair loss.
In addition, hair loss is also influenced by genetic factors, environment, oxidative stress, extracellular matrix loss, scalp blood circulation, and other factors.
According to the latest research, with the spread of the new round of COVID-19 epidemic, the number of infected people is increasing,Up to 30% of 'Yangkang' individuals experience significant hair loss symptoms after turning negative. Experts explain that this may be a complication caused by infection, as the virus triggers an inflammatory response around the hair follicles. In addition, factors such as weakened immune system and poor mental state during infection accelerate hair loss, leading to intermittent hair loss.
Anti hair loss products urgently need improvement
At present, the commonly used active ingredients in the treatment of androgenic alopecia include minoxidil, finasteride, etc. However, these ingredients have significant side effects, such as minoxidil causing hypotension, dry scalp, dandruff, scalp erythema, inflammation, irritation, etc; Finasteride has serious male hormone activity inhibition side effects. Moreover, minoxidil and finasteride are both classified as medicinal ingredients and cannot be used in cosmetics.
Scientific analysis shows that a large number of commercially available hair loss prevention cosmetic products generally have the following problems:
Limited effectiveness in preventing hair loss：Anti hair loss cosmetics generally have unclear mechanisms, single targets, and overuse of conceptual ingredients, resulting in limited effectiveness in preventing hair loss.
The product has significant side effectsThe active ingredients used in some products are prone to recurrence, leading to side effects such as obesity, emotional depression, and decreased physical strength.
Low utilization rate of functional ingredients：The anti hair loss active ingredients are difficult to penetrate into hair follicles and act on the anti hair loss target sites and target cells, greatly reducing the anti hair loss effect.
Poor product experience：Most commercially available products are tinctures containing ethanol and penetration enhancers, which can cause dry scalp, dandruff, itching, and breakageBad skin.
Baisi Kairui Solution
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Best Carrier ® Rimex
Best Carrier ® is developed based on the underlying mechanism of androgenic alopecia, utilizing innovative transdermal co delivery nanocarrier technology to combine two anti hair loss active ingredientsDiaminopyrimidine oxideandPyrrolidine diaminopyrimidine oxideScientific compounding,Inhibit the activity of 5 α reductase, reduce testosterone to dihydrotestosterone conversion, inhibit androgen overexpression and receptor binding; At the same time, activating the Wnt signaling pathway promotes the proliferation of dermal papilla cells and optimizes the hair growth cycle.
Product advantages:
(1) Two active ingredients with different mechanisms of action for preventing hair loss and growthSynergistic efficiency, multiple effects and targetsSignificantly improve the effectiveness of preventing hair loss and promoting fertility;
（2）Transdermal co delivery of nanocarriersSignificantly increase the skin storage capacity of active ingredients and the entry of dermal papilla cells, achieve sustained and controlled release, and improve the bioavailability of active ingredients;
（3）High compatibility and good water dispersibilityGood stability, suitable for different cosmetic matrices.
The results of the human efficacy evaluation of volunteers showed that,Best Carrier ® can significantly improve hair loss symptoms in the human body.
▶ Best Carrier ® Remdesi Human Efficacy Evaluation
Best Carrier ® Rimex product has been granted a Chinese invention patent authorization for a nanocomposite containing diaminopyrimidine oxide and pyrrolidine diaminopyrimidine oxide, along with its preparation method and application（Patent number ZL201910036145. X）”.
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Best Carrier ® Mifepristone
Best Carrier ® peptide utilizes innovative transdermal co delivery nanocarrier technology to deliverCopper peptide, tripeptide-1, nutmeg pentapeptide-4, acetyl tetrapeptide-3Four scientific combinations of active peptides synergistically enhance efficiency,EffectivePromote proliferation of dermal papilla cells, upregulate VEGF and bFGF, downregulate TGF - β 1 and other pathwaysAntioxidant; Promote the secretion of type III and VII collagen and laminin, maintain ECM, and anchor hair; Activate hair follicle stem cells to repair damaged hair follicles.
Nano carrier transdermal co delivery of active peptides effectively increases the skin storage capacity of active peptides and the entry of dermal papilla cells,Slow release and controlled release significantly improve the bioavailability of active peptides.
The results of the human efficacy evaluation indicate that Best Carrier ® MifepristoneAfter three months of use, the volunteers' hair output significantly increased and their hair loss symptoms improved significantly.
▶ Evaluation of the Human Efficacy of Best Carrier ® Mifepristone
The research on Best Carrier ® peptides has been published in the important SCI journal Journal of Drug Delivery Science and Technology (2022, 72: 103381) in the field of international drug delivery.
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Best Carrier ® Silicon Free Nourishing Softener
Best Carrier ® Silicon Free Nourishing Softener uses innovative nanocarrier technology,Construction of dipropylene glycol/squalane/glycerol tris (ethylhexanoate) ester composite nanoemulsion, throughNanoemulsion technologyPromote the rapid absorption of active ingredients by the scalp and hair, increase the biological adhesion on the hair,Care for hair and repair damaged hair scalesIt is a new type of scalp and hair care technology. The technical roadmap of Best Carrier ® silicon free nourishing and softening agent is shown in the following figure.
The hair was treated under UV irradiation for 48 hours, and the microstructure of the hair was observed using a scanning electron microscope (SEM). The results showed that the surface of the hair scales in the control group was rough and cracked; And using Best Carrier ® The surface of hair scales treated with silicon free nourishing and softening agents is smooth and without cracking. indicateBest Carrier ® Silicon Free Nourishing Softener can effectively protect hair from UV damage. The study also found that Best Carrier ® silicon free nourishing and softening agent can promote the proliferation of the probiotic Staphylococcus epidermidis on the scalp, and has a significant inhibitory effect on Malassezia, which is harmful to the scalp, indicating its ability toEffectively improve the scalp microbial environment and promote scalp health.
Academic papers published in research work
The R&D team of Baisi Kairui has published multiple research papers in important academic journals in the industry and international SCI journals. These papers showcase the team's research and development achievements and strong technical accumulation in the field of hair loss prevention, and also provide solid theoretical support for the application of Baisikairui transdermal co delivery nanocarrier products in hair loss prevention products.
Currently developed by Baisi KairuiAnti hair loss and hair care series transdermal co delivery nanocarrierThere are five products in total. If you want to learn more detailed information, please feel free to consult Baisi Kairui and Aoxue Chemical.
Wuhan Baisi Kairui Biotechnology Co., Ltd. always adheres to the principle of "technological innovation, customer first", providing integrated services for the research and development, production, and application of nano carriers of cosmetic functional ingredients for a wide range of cosmetic brands and enterprises. In the future, the company will continue to strengthen the research and development of nano carrier technology for cosmetic efficacy raw materials, promote the scientific application of nano carrier technology in efficacy cosmetics, improve the technological level of China's efficacy cosmetics industry, achieve precise skincare, and bring healthy, safe, and efficient new efficacy cosmetics to consumers.
